Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies.
Animals
Brain Injuries, Traumatic
/ physiopathology
Cognition Disorders
/ physiopathology
Disease Models, Animal
Epilepsy
/ physiopathology
Hippocampus
/ metabolism
Humans
Mood Disorders
/ physiopathology
Neural Stem Cells
/ pathology
Neurogenesis
/ physiology
Neurons
/ metabolism
Stroke
/ physiopathology
Epilepsy
Hippocampus
Neural stem cells
Neurogenesis
Stroke
Traumatic brain injury
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
17 10 2019
17 10 2019
Historique:
received:
14
04
2019
revised:
29
05
2019
accepted:
10
06
2019
pubmed:
15
6
2019
medline:
12
9
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Adult hippocampal neurogenesis plays a critical role in a wide spectrum of hippocampus-dependent functions. Brain pathologies that involve the hippocampus like epilepsy, stroke, and traumatic brain injury, are commonly associated with cognitive impairments and mood disorders. These insults can affect neural stem cells and the subsequent neurogenic cascade in the hippocampus, resulting in the induction of aberrant neurogenesis, which is thought to compromise hippocampal network function, thereby hampering hippocampus-dependent behavior. We here summarize recent preclinical literature on hippocampal insult-induced changes in neurogenesis and based on that, we propose that normalizing aberrant neurogenesis post-insult may help to prevent or rescue behavioral deficits which could help develop novel therapeutic strategies.
Identifiants
pubmed: 31199935
pii: S0166-4328(19)30578-9
doi: 10.1016/j.bbr.2019.112032
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112032Informations de copyright
Copyright © 2019. Published by Elsevier B.V.