Superoxide and NADPH oxidase do not modulate skin blood flow in older exercising adults with and without type 2 diabetes.
Aged
Bicycling
Diabetes Mellitus, Type 2
/ diagnosis
Enzyme Inhibitors
/ administration & dosage
Exercise
Female
Free Radical Scavengers
/ pharmacology
Hot Temperature
Humans
Male
Middle Aged
NADPH Oxidases
/ antagonists & inhibitors
Nitric Oxide
/ metabolism
Nitric Oxide Synthase
/ antagonists & inhibitors
Oxygen Consumption
Physical Fitness
Regional Blood Flow
Skin
/ blood supply
Superoxides
/ metabolism
Time Factors
Vasodilation
/ drug effects
Aging
Apocynin
Microcirculation
Reactive oxygen species
Skin blood flow
Tempol
Thermoregulation
Journal
Microvascular research
ISSN: 1095-9319
Titre abrégé: Microvasc Res
Pays: United States
ID NLM: 0165035
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
09
04
2019
revised:
09
05
2019
accepted:
11
06
2019
pubmed:
15
6
2019
medline:
6
5
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
High aerobic fitness may prevent age-related decrements in cutaneous vasodilation while type 2 diabetes may exacerbate this decline. The mechanisms underlying these responses remain unclear, but may be due to an excess of reactive oxygen species. We hypothesized that superoxide scavenging or NADPH oxidase inhibition would improve cutaneous vasodilation in older adults exercising in the heat, particularly in healthy low-fit individuals and those with type 2 diabetes. Twenty seven older adults were evenly separated into three groups (healthy low-fit: VO In all groups, L-NAME consistently reduced CVC Superoxide and NADPH oxidase do not modulate cutaneous vasodilation in healthy low- or high-fit older adults exercising in the heat, regardless of aerobic fitness level or relative exercise intensity employed, nor do they influence cutaneous vasodilation during an exercise-heat stress in those with type 2 diabetes. However, NOS remains an important modulator of cutaneous vasodilation during exercise in all groups.
Identifiants
pubmed: 31199960
pii: S0026-2862(19)30080-9
doi: 10.1016/j.mvr.2019.103886
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Free Radical Scavengers
0
Superoxides
11062-77-4
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase
EC 1.14.13.39
NADPH Oxidases
EC 1.6.3.-
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103886Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.