Lipid metabolism and Calcium signaling in epithelial ovarian cancer.
Journal
Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
27
03
2019
revised:
03
06
2019
accepted:
04
06
2019
pubmed:
15
6
2019
medline:
31
7
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Epithelial Ovarian cancer (EOC) is the deadliest gynecologic malignancy and represents the fifth leading cause of all cancer-related deaths in women. The majority of patients are diagnosed at an advanced stage of the disease that has spread beyond the ovaries to the peritoneum or to distant organs (stage FIGO III-IV) with a 5-year overall survival of about 29%. Consequently, it is necessary to understand the pathogenesis of this disease. Among the factors that contribute to cancer development, lipids and ion channels have been described to be associated to cancerous diseases particularly in breast, colorectal and prostate cancers. Here, we reviewed the literature data to determine how lipids or lipid metabolites may influence EOC risk or progression. We also highlighted the role and the expression of the calcium (Ca
Identifiants
pubmed: 31200184
pii: S0143-4160(19)30068-5
doi: 10.1016/j.ceca.2019.06.002
pii:
doi:
Substances chimiques
Lysophospholipids
0
Arachidonic Acid
27YG812J1I
lysophosphatidic acid
PG6M3969SG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-50Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.