Metazoan DNA replication origins.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
04
03
2019
accepted:
11
03
2019
pubmed:
15
6
2019
medline:
8
2
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
DNA replication starts with the opening of DNA at sites called DNA replication origins. From the single sequence-specific DNA replication origin of the small Escherichia coli genome, up to thousands of origins that are necessary to replicate the large human genome, strict sequence specificity has been lost. Nevertheless, genome-wide analyses performed in the recent years, using different mapping methods, demonstrated that there are precise locations along the metazoan genome from which replication initiates. These sites contain relaxed sequence consensus and epigenetic features. There is flexibility in the choice of origins to be used during a given cell cycle, probably imposed by evolution and developmental constraints. Here, we will briefly describe their main features.
Identifiants
pubmed: 31200185
pii: S0955-0674(18)30145-5
doi: 10.1016/j.ceb.2019.03.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
134-141Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.