Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring.
aptamer
aptasensor
optical label free-sensing
porous silicon
surface modification
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
13 Jun 2019
13 Jun 2019
Historique:
received:
29
04
2019
revised:
04
06
2019
accepted:
12
06
2019
entrez:
16
6
2019
pubmed:
16
6
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Aptamers are artificial nucleic acid ligands identified and obtained from combinatorial libraries of synthetic nucleic acids through the in vitro process SELEX (systematic evolution of ligands by exponential enrichment). Aptamers are able to bind an ample range of non-nucleic acid targets with great specificity and affinity. Devices based on aptamers as bio-recognition elements open up a new generation of biosensors called aptasensors. This review focuses on some recent achievements in the design of advanced label-free optical aptasensors using porous silicon (PSi) as a transducer surface for the detection of pathogenic microorganisms and diagnostic molecules with high sensitivity, reliability and low limit of detection (LoD).
Identifiants
pubmed: 31200538
pii: molecules24122216
doi: 10.3390/molecules24122216
pmc: PMC6630495
pii:
doi:
Substances chimiques
Aptamers, Nucleotide
0
Silicon
Z4152N8IUI
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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