Inhibition of the Hedgehog pathway in lung cancer.

Animals Antineoplastic Agents / pharmacology Carcinoma, Basal Cell / drug therapy Clinical Trials as Topic Drug Evaluation, Preclinical Hedgehog Proteins / antagonists & inhibitors Humans Lung Neoplasms / drug therapy Medulloblastoma / drug therapy Signal Transduction
Arsenic trioxide GANT61 GLI Primary cilium Smoothened Vismodegib

Journal

Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805

Informations de publication

Date de publication:
07 2019
Historique:
received: 06 02 2019
revised: 02 05 2019
accepted: 05 05 2019
entrez: 16 6 2019
pubmed: 16 6 2019
medline: 7 3 2020
Statut: ppublish

Résumé

Inhibitors of the hedgehog pathway are effective in patients with basal cell carcinoma and a subgroup of patients with medulloblastoma with active hedgehog signaling. Despite preclinical work suggesting otherwise, clinical trials in solid tumors of epithelial origin have not shown added benefit with these drugs. Here, we review the preclinical and clinical data of hedgehog pathway inhibition in the most common histologic types of lung cancer. We focus on highlighting areas of uncertainty, where further research might define a niche for hedgehog pathway inhibition in patients with lung cancer.

Identifiants

DOI: 10.1016/j.lungcan.2019.05.004 PMID: 31200829
pubmed: 31200829
pii: S0169-5002(19)30445-3
doi: 10.1016/j.lungcan.2019.05.004
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Hedgehog Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

56-61

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

A Dimou (A)

University of Colorado, Division of Medical Oncology, 12801 E. 17th Avenue, Mail Stop 8117, Research 1 South, Aurora, CO, USA. Electronic address: anastasios.dimou@ucdenver.edu.

A Bamias (A)

Alexandra Hospital, National and Kapodistrian University of Athens School of Medicine, Department of Clinical Therapeutics, Alexandra Hospital, 80 Vasilisis Sofias Avenue, Athens, Greece. Electronic address: abamias@med.uoa.gr.

H Gogas (H)

Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, 1st Department of Medicine, 17 Agiou Thoma St. Athens, Greece. Electronic address: hgogas@med.uoa.gr.

K Syrigos (K)

Sotiria Hospital, National and Kapodistrian University of Athens School of Medicine, 3rd Department of Medicine, 152 Masogeion Avenue, Athens, Greece. Electronic address: ksyrigos@med.uoa.gr.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs basocellulaires › Carcinome basocellulaire › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines Hedgehog › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Médulloblastome › Inhibition of the Hedgehog pathway in lung cancer.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Inhibition of the Hedgehog pathway in lung cancer.