Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.
Animals
Biomarkers
Cell Differentiation
Cellular Microenvironment
Cytokines
/ metabolism
Immunophenotyping
Lymph Nodes
/ cytology
Macrophages
/ immunology
Mesenchymal Stem Cells
/ metabolism
Mice
Mice, Transgenic
RANK Ligand
/ metabolism
Receptor Activator of Nuclear Factor-kappa B
/ metabolism
Signal Transduction
Stromal Cells
/ metabolism
RANK
lymph node
lymphatic endothelial cells
macrophages
mesenchymal stromal cells
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
18 06 2019
18 06 2019
Historique:
received:
30
10
2018
revised:
06
04
2019
accepted:
15
05
2019
pubmed:
16
6
2019
medline:
2
11
2019
entrez:
16
6
2019
Statut:
ppublish
Résumé
Tissue-resident macrophages are receptive to specific signals concentrated in cellular niches that direct their cell differentiation and maintenance genetic programs. Here, we found that deficiency of the cytokine RANKL in lymphoid tissue organizers and marginal reticular stromal cells of lymph nodes resulted in the loss of the CD169
Identifiants
pubmed: 31201093
pii: S1074-7613(19)30228-6
doi: 10.1016/j.immuni.2019.05.008
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
RANK Ligand
0
Receptor Activator of Nuclear Factor-kappa B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1467-1481.e6Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.