E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
Animals
Basic Helix-Loop-Helix Transcription Factors
/ genetics
CD8 Antigens
/ metabolism
Cell Differentiation
/ genetics
Chemokine CXCL12
/ metabolism
Epithelial Cells
/ metabolism
Humans
Lymphopoiesis
/ genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Antigen, T-Cell
/ metabolism
Receptors, CXCR4
/ genetics
Signal Transduction
/ genetics
Thymocytes
/ metabolism
Thymus Gland
/ metabolism
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
05 08 2019
05 08 2019
Historique:
received:
11
12
2018
revised:
14
02
2019
accepted:
20
05
2019
pubmed:
16
6
2019
medline:
20
6
2020
entrez:
16
6
2019
Statut:
ppublish
Résumé
Preselection thymocytes are normally retained in the thymic cortex, but the mechanisms responsible remain incompletely understood. We now report that deletion of genes encoding the E-protein transcription factors E2A and HEB disorders chemokine receptor expression on developing thymocytes to allow escape of preselection TCR
Identifiants
pubmed: 31201207
pii: jem.20182285
doi: 10.1084/jem.20182285
pmc: PMC6683992
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
CD8 Antigens
0
CXCR4 protein, human
0
Chemokine CXCL12
0
Cxcl12 protein, mouse
0
Receptors, Antigen, T-Cell
0
Receptors, CXCR4
0
Tcf12 protein, mouse
0
Tcf3 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1749-1761Subventions
Organisme : NIAID NIH HHS
ID : P01 AI102853
Pays : United States
Informations de copyright
© 2019 Kadakia et al.
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