Loss of dysbindin-1 affects GABAergic transmission in the PFC.
Animals
Dysbindin
/ deficiency
GABAergic Neurons
/ metabolism
Inhibitory Postsynaptic Potentials
/ physiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Patch-Clamp Techniques
/ methods
Prefrontal Cortex
/ metabolism
Pyramidal Cells
/ metabolism
Receptors, N-Methyl-D-Aspartate
/ metabolism
Synaptic Transmission
/ physiology
Dysbindin-1
GABA
Interneurons
Prefrontal cortex
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
06
02
2019
accepted:
24
05
2019
pubmed:
16
6
2019
medline:
29
1
2020
entrez:
16
6
2019
Statut:
ppublish
Résumé
It has been shown that dystrobrevin-binding protein 1 gene that encodes the protein dysbindin-1 is associated with risk for cognitive deficits, and studies have shown decreases in glutamate and correlated decreases in dysbindin-1 protein in the prefrontal cortex (PFC) and hippocampus of post-mortem tissue from schizophrenia patients. The PFC and the hippocampus have been shown to play a fundamental role in cognition, and studies in dysbindin-1 null mice have shown alterations in NMDAR located in pyramidal neurons as well as perturbation in LTP and cognitive deficits. The balance between excitatory and inhibitory transmission is crucial for normal cognitive functions; however, there is a dearth of information regarding the effects of loss of dysbindin-1 in GABAergic transmission. Using in vitro whole-cell clamp recordings, Western blots, and immunohistochemistry, we report here that dysbindin-1-deficient mice exhibit a significant decrease in the frequency of sIPSCs and in the amplitude of mIPSCs and significant decreases in PV staining and protein level. These results suggest that loss of dysbindin-1 affects GABAergic transmission at pre- and postsynaptic level and decreases parvalbumin markers.
Identifiants
pubmed: 31201475
doi: 10.1007/s00213-019-05285-1
pii: 10.1007/s00213-019-05285-1
pmc: PMC6832803
mid: NIHMS1531948
doi:
Substances chimiques
Dysbindin
0
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3291-3300Subventions
Organisme : NIMH NIH HHS
ID : RL1 MH083269
Pays : United States
Références
Schizophr Res Cogn. 2017 Mar 09;8:1-6
pubmed: 28740825
Behav Brain Res. 2013 Mar 15;241:173-84
pubmed: 23261874
Neuropsychopharmacology. 2009 Nov;34(12):2601-8
pubmed: 19641486
Mol Neurobiol. 2011 Aug;44(1):53-64
pubmed: 21520000
Mol Psychiatry. 2011 Feb;16(2):145-55
pubmed: 20010894
Neuron. 2014 Mar 5;81(5):1126-1139
pubmed: 24607232
Science. 2009 Nov 20;326(5956):1127-30
pubmed: 19965435
Mol Psychiatry. 2014 Mar;19(3):311-6
pubmed: 24145376
J Neurosci. 2015 Jan 7;35(1):325-38
pubmed: 25568125
Biol Psychiatry. 2011 Jan 1;69(1):28-34
pubmed: 21035792
Mol Psychiatry. 2007 Jan;12(1):74-86
pubmed: 17043677
Mol Biol Cell. 2011 Dec;22(24):4854-67
pubmed: 21998198
Genes Brain Behav. 2009 Jun;8(4):390-7
pubmed: 19220483
Curr Opin Neurobiol. 2014 Jun;26:22-6
pubmed: 24650500
J Neurosci. 2010 Jan 20;30(3):820-31
pubmed: 20089890
Biochem Biophys Res Commun. 2006 Jun 30;345(2):904-9
pubmed: 16701550
Neurobiol Dis. 2019 Nov;131:104208
pubmed: 29936230
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5341-6
pubmed: 9560277
Mol Psychiatry. 2008 Feb;13(2):147-61
pubmed: 17471287
Biol Psychiatry. 2018 Dec 1;84(11):787-796
pubmed: 30177255
Behav Brain Funct. 2007 Apr 20;3:19
pubmed: 17445278
Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):841-9
pubmed: 22911901
Neuropharmacology. 2015 Jan;88:91-8
pubmed: 25261782
Hum Mol Genet. 2015 Oct 1;24(19):5512-23
pubmed: 26199316
Biol Psychiatry. 2010 Dec 15;68(12):1126-33
pubmed: 21130223
Neural Plast. 2011;2011:723184
pubmed: 21904685
J Neurosci. 2014 Oct 8;34(41):13725-36
pubmed: 25297099
Biol Psychiatry. 2016 Aug 15;80(4):312-322
pubmed: 26386481
Nat Rev Neurosci. 2004 Oct;5(10):793-807
pubmed: 15378039
Nat Commun. 2018 Aug 29;9(1):3560
pubmed: 30158661
J Neurosci. 2016 Dec 7;36(49):12393-12411
pubmed: 27927957
J Neurosci. 2012 Jun 20;32(25):8716-24
pubmed: 22723711
Schizophr Bull. 2008 Sep;34(5):944-61
pubmed: 18586694
Schizophr Res. 2002 May 1;55(1-2):1-10
pubmed: 11955958
Arch Gen Psychiatry. 2004 Jun;61(6):544-55
pubmed: 15184234
Br J Pharmacol. 2017 Oct;174(19):3211-3225
pubmed: 28477384
Neuron. 2000 Oct;28(1):53-67
pubmed: 11086983
Transl Psychiatry. 2019 Apr 9;9(1):132
pubmed: 30967545
Cereb Cortex. 1997 Sep;7(6):476-86
pubmed: 9276173
Mol Psychiatry. 2010 Feb;15(2):115, 204-15
pubmed: 19546860
Biol Psychiatry. 2011 Jan 1;69(1):2-4
pubmed: 21145442
Cereb Cortex. 2003 Nov;13(11):1242-50
pubmed: 14576215
Biol Psychiatry. 2018 Apr 15;83(8):638-647
pubmed: 29275839
Cogn Neuropsychiatry. 2015;20(2):144-56
pubmed: 25530342
Trends Neurosci. 2004 Nov;27(11):683-90
pubmed: 15474169
Curr Pharm Biotechnol. 2012 Jun;13(8):1513-21
pubmed: 22283763
Schizophr Res. 2007 Jan;89(1-3):169-72
pubmed: 17074466
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E962-70
pubmed: 21969553
J Clin Invest. 2004 May;113(9):1353-63
pubmed: 15124027
Trends Neurosci. 2003 Dec;26(12):676-82
pubmed: 14624852
Adv Neurobiol. 2017;15:255-280
pubmed: 28674984
Neuroreport. 2004 Aug 6;15(11):1809-12
pubmed: 15257153
Science. 2007 Jun 15;316(5831):1609-12
pubmed: 17569862
J Neurosci. 2003 Aug 13;23(19):7407-11
pubmed: 12917376
Arch Neurol. 2006 Oct;63(10):1372-6
pubmed: 17030651
Hum Mol Genet. 2009 Oct 15;18(20):3851-63
pubmed: 19617633
Hippocampus. 2014 Feb;24(2):204-13
pubmed: 24446171
Mol Psychiatry. 2017 Jul;22(7):936-943
pubmed: 28322275
Mol Psychiatry. 2012 Jan;17(1):85-98
pubmed: 20956979
ASN Neuro. 2011 May 27;3(2):
pubmed: 21504412
Front Genet. 2017 Mar 10;8:28
pubmed: 28344592
Nat Rev Neurosci. 2016 Aug;17(8):524-32
pubmed: 27256556
Cereb Cortex. 2016 Feb;26(2):576-85
pubmed: 25246509
Mol Psychiatry. 2019 May;24(5):633-642
pubmed: 30242229
Annu Rev Pharmacol Toxicol. 2001;41:237-60
pubmed: 11264457
Schizophr Res. 2013 May;146(1-3):254-63
pubmed: 23473812
Nat Rev Neurosci. 2005 Apr;6(4):312-24
pubmed: 15803162
Mol Biol Cell. 2009 Mar;20(5):1441-53
pubmed: 19144828
Brain Res Rev. 2006 Sep;52(2):293-304
pubmed: 16759710
J Cell Biol. 2008 Jun 2;181(5):791-801
pubmed: 18504299
J Biol Chem. 2004 Jul 2;279(27):28393-401
pubmed: 15102850
J Neurosci. 2000 Jan 1;20(1):485-94
pubmed: 10627624
Curr Biol. 2014 Dec 15;24(24):2878-87
pubmed: 25454585
Trends Neurosci. 2012 Jan;35(1):57-67
pubmed: 22154068
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19593-8
pubmed: 19887632
J Neural Transm (Vienna). 2006 Sep;113(9):1337-46
pubmed: 16463116
Cogn Neuropsychiatry. 2003 Feb;8(1):57-71
pubmed: 16571550
Schizophr Res. 2008 Jan;98(1-3):105-10
pubmed: 17961984