Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity.
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
28
11
2018
entrez:
16
6
2019
pubmed:
16
6
2019
medline:
19
7
2019
Statut:
ppublish
Résumé
Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5-48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.
Identifiants
pubmed: 31201630
doi: 10.1134/S1607672919020121
pii: 10.1134/S1607672919020121
doi:
Substances chimiques
Analgesics
0
Brain-Derived Neurotrophic Factor
0
Dipeptides
0
Peptidomimetics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-125Références
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