Genomic medicine in Chagas disease.
Association studies
Genetic risk factors
Neglected tropical disease
Personalized medicine
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
11
03
2019
accepted:
11
06
2019
pubmed:
16
6
2019
medline:
23
11
2019
entrez:
16
6
2019
Statut:
ppublish
Résumé
Genetic approaches have been proposed for improving the understanding of the causes of differential susceptibility to Trypanosoma cruzi infection and Chagas disease outcome. Polymorphisms in genes involved in the immune/inflammatory response are being studied in order to clarify their possible role in the occurrence or severity of the cardiac and/or gastrointestinal complications. However still today, the number of significant associated genes is limited and the pathophysiological mechanisms underlying this condition are unknown. This article review the information currently available from the published scientific literature regarding the genetic variants of molecules of the immune system and other variants that can contribute to the clinical presentation of the disease. Genomic medicine will improve our knowledge about the molecular basis of Chagas disease, will open new avenues for developing biomarkers of disease progression, new therapeutic strategies to suit the requirements of individual patients, and will contribute to the control of one of the infections with the greatest socio-economic impact in the Americas.
Identifiants
pubmed: 31201776
pii: S0001-706X(19)30229-3
doi: 10.1016/j.actatropica.2019.105062
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105062Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.