Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands.

Adrenal Glands / chemistry Aldosterone / analysis Glucocorticoids / analysis Humans Hydrocortisone / analogs & derivatives Isomerism Mineralocorticoids / analysis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Steroids / analysis Tandem Mass Spectrometry / methods

Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
16 07 2019
Historique:
pubmed: 18 6 2019
medline: 25 9 2020
entrez: 18 6 2019
Statut: ppublish

Résumé

Visualizing tissue distribution of steroid hormones is a promising application of MALDI mass spectrometry imaging (MSI). On-tissue chemical derivatization using Girard's T reagent has enhanced the ionization efficiency of steroids. However, discriminating between structural isomers with distinct bioactivities remains a challenge. Herein, we used ion trap MS/tandem MS (MS

Identifiants

DOI: 10.1021/acs.analchem.9b00619 PMID: 31204806
pubmed: 31204806
doi: 10.1021/acs.analchem.9b00619
doi:

Substances chimiques

Glucocorticoids 0
Mineralocorticoids 0
Steroids 0
18-oxocortisol 2410-60-8
Aldosterone 4964P6T9RB
18-hydroxycortisol T8YUY43659
Hydrocortisone WI4X0X7BPJ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8918-8925

Auteurs

Emi Takeo (E)

Department of Biotechnology, Graduate School of Engineering , Osaka University , 2-1 Yamadaoka , Suita , Osaka 565-0871 , Japan.

Yuki Sugiura (Y)

Department of Biochemistry , Keio University School of Medicine , 35 Shinanomachi , Shinjuku-ku, Tokyo 160-8582 , Japan.

Tatsuki Uemura (T)

Department of Pharmaceutical Microbiology, Faculty of Life Sciences , Kumamoto University , 5-1 Oe-honmachi , Chuo-ku, Kumamoto 862-0973 , Japan.

Koshiro Nishimoto (K)

Department of Biochemistry , Keio University School of Medicine , 35 Shinanomachi , Shinjuku-ku, Tokyo 160-8582 , Japan.
Department of Uro-Oncology , Saitama Medical University International Medical Center , 1397-1 Yamane , Hidaka , Saitama 350-1298 , Japan.

Masanori Yasuda (M)

Department of Pathology , Saitama Medical University International Medical Center , 1397-1 Yamane , Hidaka , Saitama 350-1298 , Japan.

Eiji Sugiyama (E)

Department of Biochemistry , Keio University School of Medicine , 35 Shinanomachi , Shinjuku-ku, Tokyo 160-8582 , Japan.

Sumio Ohtsuki (S)

Department of Pharmaceutical Microbiology, Faculty of Life Sciences , Kumamoto University , 5-1 Oe-honmachi , Chuo-ku, Kumamoto 862-0973 , Japan.
ORCID: 0000-0003-4634-7133

Tatsuya Higashi (T)

Faculty of Pharmaceutical Sciences , Tokyo University of Science , 2641 Yamazaki , Noda , Chiba 278-8510 , Japan.

Tetsuo Nishikawa (T)

Endocrinology and Diabetes Center , Yokohama Rosai Hospital , 3211 Kozukuecho , Kohoku-ku, Yokohama , Kanagawa 222-0036 , Japan.

Makoto Suematsu (M)

Department of Biochemistry , Keio University School of Medicine , 35 Shinanomachi , Shinjuku-ku, Tokyo 160-8582 , Japan.

Eiichiro Fukusaki (E)

Department of Biotechnology, Graduate School of Engineering , Osaka University , 2-1 Yamadaoka , Suita , Osaka 565-0871 , Japan.

Shuichi Shimma (S)

Department of Biotechnology, Graduate School of Engineering , Osaka University , 2-1 Yamadaoka , Suita , Osaka 565-0871 , Japan.
ORCID: 0000-0002-4699-6590

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Classifications MeSH

questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 11-Hydroxycorticostéroïdes › Aldostérone › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Minéralocorticoïdes › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse MALDI › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Tandem Mass Spectrometry Imaging Reveals...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Tandem Mass Spectrometry Imaging Reveals...