Is there a role for cherries in the management of gout?
anthocyanins
anti-inflammatory
cherries
gout
quercetin
serum urate
tart cherry
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
11
2018
accepted:
28
03
2019
entrez:
18
6
2019
pubmed:
18
6
2019
medline:
18
6
2019
Statut:
epublish
Résumé
Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. Patients with gout often have a multitude of comorbidities, leading to concern over drug-drug interactions and medication adverse events. The cherry is a small nutrient-rich fruit that has garnered a great deal of attention in recent years as a nonpharmacologic option for the treatment of a multitude of disease manifestations. Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy. In this review, we explore the potential benefits of cherries and cherry products as a nonpharmacologic option for the treatment of gout.
Identifiants
pubmed: 31205513
doi: 10.1177/1759720X19847018
pii: 10.1177_1759720X19847018
pmc: PMC6535740
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1759720X19847018Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declare that there is no conflict of interest.
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