Thrombocytopenia in solid tumors: Prognostic significance.
Thrombocytopenia
chemotherapy
cytokines polymorphism
solid tumors
Journal
Oncology reviews
ISSN: 1970-5565
Titre abrégé: Oncol Rev
Pays: Switzerland
ID NLM: 101519906
Informations de publication
Date de publication:
14 Jan 2019
14 Jan 2019
Historique:
received:
18
01
2019
accepted:
18
03
2019
entrez:
18
6
2019
pubmed:
18
6
2019
medline:
18
6
2019
Statut:
epublish
Résumé
Solid tumors are a heterogeneous group of malignancies that result from out-of-control proliferation of cells. Thrombocytopenia is a common complication among patients with solid tumors that predispose them to bleeding disorders. The aim of this review article is to investigate the underlying mechanisms of the risk and incidence of thrombocytopenia in solid tumors. It can be argued that thrombocytopenia is a poor prognostic factor in solid tumors that can result from several factors such as polymorphism and mutation in some transcription factors and cytokines involved in megakaryocytic maturation or from the adverse effects of treatment. Therefore, an understanding of the exact mechanism of thrombocytopenia pathogenesis in each stage of solid tumors can help in developing therapeutic strategies to decrease bleeding complications in these malignancies.
Identifiants
pubmed: 31205603
doi: 10.4081/oncol.2019.413
pmc: PMC6542370
doi:
Types de publication
Journal Article
Langues
eng
Pagination
413Déclaration de conflit d'intérêts
Conflict of interest: The authors declare no conflict of interest.
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