West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature.
CCR5
Chronic Lymphocytic Leukemia
Encephalitis
West Nile Virus
Journal
Mediterranean journal of hematology and infectious diseases
ISSN: 2035-3006
Titre abrégé: Mediterr J Hematol Infect Dis
Pays: Italy
ID NLM: 101530512
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
01
2019
accepted:
03
04
2019
entrez:
18
6
2019
pubmed:
18
6
2019
medline:
18
6
2019
Statut:
epublish
Résumé
West Nile virus is a zoonotic agent causing life-threatening encephalitis in a proportion of infected patients. Older age, immunosuppression, and mutations in specific host genes (e.g., CCR5 delta-32 mutation) predispose to neuroinvasive infection. We report on two cases of severe West Nile encephalitis in recently-treated, different-aged, chronic lymphocytic leukemia patients. Both patients developed high-grade fever associated with severe neurological impairment. The younger one harboured germ-line CCR5 delta-32 mutation, which might have played a role in the pathogenesis of its neuroinvasive manifestations.
Identifiants
pubmed: 31205637
doi: 10.4084/MJHID.2019.033
pii: mjhid-11-1-e2019033
pmc: PMC6548214
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e2019033Déclaration de conflit d'intérêts
Competing interests: The authors have declared that no competing interests exist.
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