Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso.
Burkina Faso
epidemiology
hepatitis E virus
risk factors
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
14 06 2019
14 06 2019
Historique:
received:
17
05
2019
revised:
06
06
2019
accepted:
12
06
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
25
7
2020
Statut:
epublish
Résumé
Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.
Identifiants
pubmed: 31207982
pii: v11060554
doi: 10.3390/v11060554
pmc: PMC6630816
pii:
doi:
Substances chimiques
Hepatitis Antibodies
0
Immunoglobulin G
0
Immunoglobulin M
0
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.
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