Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy.
collagen deposition
diagnostic biomarkers
oral submucous fibrosis (OSF)
precancerous disorder
therapeutic interventions
underlying mechanisms
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jun 2019
16 Jun 2019
Historique:
received:
14
05
2019
revised:
10
06
2019
accepted:
14
06
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
30
11
2019
Statut:
epublish
Résumé
Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5-15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.
Identifiants
pubmed: 31208114
pii: ijms20122940
doi: 10.3390/ijms20122940
pmc: PMC6627879
pii:
doi:
Substances chimiques
Biomarkers
0
Collagen
9007-34-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : China Medical University
ID : CMU107-S-37
Organisme : Ministry of Science and Technology
ID : MOST 106-2314-B-039-003-MY2
Organisme : Ministry of Science and Technology
ID : MOST 107-2314-B-468 -007
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