Macropinocytosis in Cancer: A Complex Signaling Network.
AMPK
PTEN
Ras
Wnt
integrin αvβ3
macropinocytosis
metabolism
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
22
03
2019
revised:
10
04
2019
accepted:
11
04
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
2
7
2020
Statut:
ppublish
Résumé
Macropinocytosis is an important nutrient-scavenging pathway in numerous cancer types, including pancreatic, lung, prostate, and bladder. This Forum highlights recent work identifying the key regulators of macropinocytosis that support tumor cell fitness in different contexts, providing a unique framework for strategies to target macropinocytosis in the treatment of cancer.
Identifiants
pubmed: 31208695
pii: S2405-8033(19)30072-X
doi: 10.1016/j.trecan.2019.04.002
pmc: PMC7325493
mid: NIHMS1600460
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Letter
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-334Subventions
Organisme : NCI NIH HHS
ID : R01 CA207189
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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