Epigenome Remodeling in Cholangiocarcinoma.

Bile Duct Neoplasms / genetics Biomarkers, Tumor Cell Transformation, Neoplastic Cellular Reprogramming / genetics Cholangiocarcinoma / genetics DNA Methylation Epigenesis, Genetic Epigenome Epigenomics / methods Gene Expression Regulation, Neoplastic Genetic Heterogeneity Genetic Predisposition to Disease Histones / metabolism Humans Mutation Tumor Microenvironment / genetics
DNA methylation biliary tract cancer cholangiocarcinoma epigenomics

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
06 2019
Historique:
received: 15 12 2018
revised: 03 05 2019
accepted: 07 05 2019
entrez: 19 6 2019
pubmed: 19 6 2019
medline: 2 7 2020
Statut: ppublish

Résumé

Cholangiocarcinoma (CCA) comprises a heterogeneous collection of malignancies arising within the biliary tract, characterized by late diagnosis, innate chemoresistance, and abysmal prognosis. Sequencing data have uncovered recurrent mutations in diverse epigenetic regulators, implicating epigenetic destabilization at the root of these tumors. However, few studies have characterized biliary tumor epigenomes. In this Opinion article, we argue that an epigenome-oriented approach to CCA could establish diverse interconnections between many key aspects of research on this disease, including molecular heterogeneity, diverse cells of origin, and prominent tumor microenvironments. Moreover, we discuss plausible causes of epigenome dysregulation in biliary tumors, including genetic, epigenetic, metabolic, microenvironmental, and physiological factors. Lastly, we assess the translational potential of epigenomics in CCA to uncover robust biomarkers and therapeutic opportunities for this growing group of patients with limited treatment options.

Identifiants

DOI: 10.1016/j.trecan.2019.05.002 PMID: 31208696
pubmed: 31208696
pii: S2405-8033(19)30076-7
doi: 10.1016/j.trecan.2019.05.002
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
Histones 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-350

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Colm J O'Rourke (CJ)

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

Juan Lafuente-Barquero (J)

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

Jesper B Andersen (JB)

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: jesper.andersen@bric.ku.dk.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Tumeurs de l'appareil digestif › Tumeurs des voies biliaires › Tumeurs des canaux biliaires › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Cholangiocarcinome › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Hétérogénéité génétique › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Epigenome Remodeling in Cholangiocarcinoma.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Epigenome Remodeling in Cholangiocarcinoma.