Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB).
DNA adducts
Human placenta
Polycyclic aromatic hydrocarbons
Preterm birth
Superfund sites
Unbiased metabolomics
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
20 08 2019
20 08 2019
Historique:
received:
06
06
2019
accepted:
09
06
2019
pubmed:
19
6
2019
medline:
2
7
2020
entrez:
19
6
2019
Statut:
ppublish
Résumé
The preterm birth (PTB) rate in Harris County, Texas, exceeds the U.S. rate (11.4% vs.9.6%), and there are 15 active Superfund sites in Harris County. Polycyclic aromatic hydrocarbons (PAHs) are contaminants of concern (COC) at Superfund sites across the nation. In this investigation, we tested the hypothesis that higher levels of exposure to PAHs and PAH-DNA adducts in placenta of women living near Superfund sites contribute to the increased rate of PTBs. Levels of benzo[a]pyene (BP), benzo[b]fluorene (BbF) and dibenz[a,h]anthracene (DBA), were higher in placentae from preterm deliveries compared with term deliveries in women living near Superfund sites, whereas this was not the case for women living in non-Superfund site areas. Among the PAHs, DBA levels were significantly higher than BP or BbF, and DBA levels were inversely correlated with gestational age at delivery and birth weight. Bulky PAH-DNA adducts are more prevalent in placental tissue from individuals residing near Superfund sites. Expression of Ah receptor (AHR) and NF-E2-related factor 2 (NRF2) was decreased in preterm deliveries in subjects residing near Superfund sites. Unbiased metabolomics revealed alterations in pathways involved in pentose phosphate, inositol phosphate and starch and sucrose metabolism in preterm subjects in Superfund site areas. In summary, this is the first report showing an association between PAH levels, DNA adducts, and modulation of endogenous metabolic pathways with PTBs in subjects residing near Superfund sites, and further studies could lead to novel strategies in the understanding of the mechanisms by which PAHs contribute to PTBs in women.
Identifiants
pubmed: 31208719
pii: S0006-291X(19)31175-1
doi: 10.1016/j.bbrc.2019.06.049
pmc: PMC6637943
mid: NIHMS1531986
pii:
doi:
Substances chimiques
DNA Adducts
0
Polycyclic Aromatic Hydrocarbons
0
polycyclic aromatic hydrocarbons-DNA adduct
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
344-349Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL129794
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES027725
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM056929
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA216426
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD075858
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029382
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM069234
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES009132
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220297
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD075858
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES007373
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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