Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk.
Aged
Aged, 80 and over
Cerebral Small Vessel Diseases
/ diagnostic imaging
Cross-Sectional Studies
Electromyography
Evoked Potentials, Motor
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Motor Activity
Motor Cortex
/ diagnostic imaging
Muscle Contraction
Muscle, Skeletal
/ innervation
Neural Conduction
Pyramidal Tracts
/ diagnostic imaging
Registries
Risk Assessment
Risk Factors
Time Factors
Transcranial Magnetic Stimulation
White Matter
/ diagnostic imaging
Cerebral small vessel disease
central motor conduction time
enlarged perivascular spaces
motor evoked potential
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
05
02
2019
revised:
24
05
2019
accepted:
25
05
2019
pubmed:
19
6
2019
medline:
14
8
2019
entrez:
19
6
2019
Statut:
ppublish
Résumé
Cerebral small vessel disease (CSVD) is related to motor function disturbance. It includes several types: lacunar infarction, white matter hyperintensity, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS). Transcranial magnetic stimulation (TMS) has been successfully used to evaluate the function of the pyramidal tract. Central motor conduction time (CMCT) is one of the indicators of pyramidal tract dysfunction in motor evoked potential (MEP). The aim of this study was to investigate the association between each type of CSVD and CMCT. We enrolled 350 patients with vascular risk factors or a history of cerebrovascular events, who showed signs of CSVD in magnetic resonance imaging in the prospective registry. Among them, 138 patients agreed to the evaluation of MEP. CMCT, resting motor threshold (RMT), and silent period are indicators of the function of motor pathways in MEP. A total of 276 hemispheres were divided into 45 symptomatic hemispheres with a history of pyramidal tract dysfunction and 231 without it. Correlation between each type of CSVD and CMCT were examined in total, symptomatic, and asymptomatic hemispheres. The mean age was 70.5 ± 10.3 (mean ± SD) years, and 89 (65%) were men. In the symptomatic hemisphere, CMCT and RMT were significantly higher than in the asymptomatic hemisphere. In the symptomatic hemisphere, significant association was observed between the number of EPVS in the white matter and CMCT (R In the symptomatic hemispheres, CMCT was associated with the number of EPVS in the white matter. The EPVS in the white matter may be involved in the motor disturbance due to CSVD.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Cerebral small vessel disease (CSVD) is related to motor function disturbance. It includes several types: lacunar infarction, white matter hyperintensity, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS). Transcranial magnetic stimulation (TMS) has been successfully used to evaluate the function of the pyramidal tract. Central motor conduction time (CMCT) is one of the indicators of pyramidal tract dysfunction in motor evoked potential (MEP). The aim of this study was to investigate the association between each type of CSVD and CMCT.
METHODS
METHODS
We enrolled 350 patients with vascular risk factors or a history of cerebrovascular events, who showed signs of CSVD in magnetic resonance imaging in the prospective registry. Among them, 138 patients agreed to the evaluation of MEP. CMCT, resting motor threshold (RMT), and silent period are indicators of the function of motor pathways in MEP. A total of 276 hemispheres were divided into 45 symptomatic hemispheres with a history of pyramidal tract dysfunction and 231 without it. Correlation between each type of CSVD and CMCT were examined in total, symptomatic, and asymptomatic hemispheres.
RESULTS
RESULTS
The mean age was 70.5 ± 10.3 (mean ± SD) years, and 89 (65%) were men. In the symptomatic hemisphere, CMCT and RMT were significantly higher than in the asymptomatic hemisphere. In the symptomatic hemisphere, significant association was observed between the number of EPVS in the white matter and CMCT (R
CONCLUSIONS
CONCLUSIONS
In the symptomatic hemispheres, CMCT was associated with the number of EPVS in the white matter. The EPVS in the white matter may be involved in the motor disturbance due to CSVD.
Identifiants
pubmed: 31208821
pii: S1052-3057(19)30267-8
doi: 10.1016/j.jstrokecerebrovasdis.2019.05.030
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2343-2350Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.