Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.
Acetylation
Animals
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Cell Survival
Cyclin-Dependent Kinase Inhibitor p27
/ genetics
Female
Gene Expression Regulation, Neoplastic
Histone Deacetylase 6
/ metabolism
Male
Mice
Microtubule Proteins
/ genetics
Ovarian Neoplasms
/ genetics
Protein Stability
Smad3 Protein
/ metabolism
Spermatogenesis
Spermatozoa
/ cytology
Tubulin
/ chemistry
CTA
Tekt5
cancer cell
germ cell
Journal
Molecular and cellular biology
ISSN: 1098-5549
Titre abrégé: Mol Cell Biol
Pays: United States
ID NLM: 8109087
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
10
04
2019
accepted:
06
06
2019
pubmed:
19
6
2019
medline:
28
1
2020
entrez:
19
6
2019
Statut:
epublish
Résumé
The cancer/testis antigen (CTA) genes were identified as human genes preferentially expressed in cancer cells and testis, but the contribution of CTAs to cancer and male germ cell development is unclear. In this study, we comprehensively examined mouse CTA functions and found that the majority of CTAs are involved in growth and/or survival of cancer cells. We focused on one mouse CTA gene,
Identifiants
pubmed: 31208979
pii: MCB.00154-19
doi: 10.1128/MCB.00154-19
pmc: PMC6692122
pii:
doi:
Substances chimiques
Cdkn1b protein, mouse
0
Microtubule Proteins
0
Smad3 Protein
0
Smad3 protein, mouse
0
Tubulin
0
tektins
0
Cyclin-Dependent Kinase Inhibitor p27
147604-94-2
Hdac6 protein, mouse
EC 3.5.1.98
Histone Deacetylase 6
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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