Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.

Animals Cell Line Cyclic AMP / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 / drug effects Dogs Enzyme Activation / drug effects Humans Madin Darby Canine Kidney Cells Phosphorylation Polycystic Kidney Diseases / metabolism Protein Isoforms

ADPKD PDE4 PDE4 activator cyclic AMP phosphodiesterase

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
02 07 2019

Historique:

pubmed: 19 6 2019

medline: 9 4 2020

entrez: 19 6 2019

Statut: ppublish

Résumé

Cyclic AMP (cAMP) phosphodiesterase-4 (PDE4) enzymes degrade cAMP and underpin the compartmentalization of cAMP signaling through their targeting to particular protein complexes and intracellular locales. We describe the discovery and characterization of a small-molecule compound that allosterically activates PDE4 long isoforms. This PDE4-specific activator displays reversible, noncompetitive kinetics of activation (increased

Identifiants

DOI: 10.1073/pnas.1822113116 PMID: 31209056 PMC: PMC6613170

pubmed: 31209056

pii: 1822113116

doi: 10.1073/pnas.1822113116

pmc: PMC6613170

doi:

Substances chimiques

Protein Isoforms 0

Cyclic AMP E0399OZS9N

Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11

Cyclic Nucleotide Phosphodiesterases, Type 4 EC 3.1.4.17

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

13320-13329

Informations de copyright

Déclaration de conflit d'intérêts

Conflict of interest statement: D.J.P.H., F.O., J.E.F., R.W.A., Z.J., G.C., C.M., A.L.M., K.B., J.M.A., D.R.A., and M.D.H. are employees of Mironid, Limited. N.J.P., E.K., and A.C.M.O. act as consultants to Mironid, Limited.

Références

EMBO J. 1999 Feb 15;18(4):893-903

pubmed: 10022832

J Biol Chem. 1999 Apr 23;274(17):11796-810

pubmed: 10206997

Mol Biol Cell. 1999 Dec;10(12):4355-67

pubmed: 10588663

J Biol Chem. 2000 Apr 7;275(14):10349-58

pubmed: 10744723

J Biol Chem. 2000 Apr 14;275(15):10831-7

pubmed: 10753877

Br J Pharmacol. 2000 Oct;131(4):811-9

pubmed: 11030732

Prog Nucleic Acid Res Mol Biol. 2001;69:249-315

pubmed: 11550796

Mol Pharmacol. 2001 Nov;60(5):1100-11

pubmed: 11641439

J Am Soc Nephrol. 2002 Mar;13(3):595-603

pubmed: 11856762

Br J Pharmacol. 2002 Jun;136(3):421-33

pubmed: 12023945

J Neurochem. 2002 May;81(4):745-57

pubmed: 12065634

J Biol Chem. 2002 Sep 27;277(39):35980-9

pubmed: 12121997

J Biol Chem. 2002 Oct 25;277(43):40212-21

pubmed: 12177055

FEBS Lett. 2002 Oct 23;530(1-3):53-8

pubmed: 12387865

Biochem J. 2003 Feb 15;370(Pt 1):1-18

pubmed: 12444918

J Biol Chem. 2003 Feb 21;278(8):5493-6

pubmed: 12493749

J Pharmacol Exp Ther. 2003 May;305(2):565-72

pubmed: 12704225

Physiol Rev. 2004 Jan;84(1):137-67

pubmed: 14715913

J Biol Chem. 2004 Jul 16;279(29):30338-48

pubmed: 15131123

Kidney Int. 2004 Nov;66(5):1926-38

pubmed: 15496164

J Biol Chem. 2005 Sep 30;280(39):33178-89

pubmed: 16030021

Drug Discov Today. 2005 Nov 15;10(22):1503-19

pubmed: 16257373

Biochem J. 2006 Jan 1;393(Pt 1):21-41

pubmed: 16336197

Psychopharmacology (Berl). 2006 Jun;186(2):209-17

pubmed: 16586089

Kidney Int. 2007 Jul;72(2):157-65

pubmed: 17396115

Circ Res. 2007 Apr 13;100(7):950-66

pubmed: 17431197

J Biol Chem. 2007 Nov 23;282(47):34235-49

pubmed: 17855344

J Am Soc Nephrol. 2008 Jul;19(7):1300-10

pubmed: 18385427

Trends Biochem Sci. 2010 Feb;35(2):91-100

pubmed: 19864144

Curr Pharm Des. 2010;16(9):1114-25

pubmed: 20030615

Nat Biotechnol. 2010 Jan;28(1):63-70

pubmed: 20037581

Nat Biotechnol. 2010 Jan;28(1):38-40

pubmed: 20062038

Biochim Biophys Acta. 2011 Oct;1812(10):1291-300

pubmed: 21118718

J Mol Med (Berl). 2011 Mar;89(3):251-61

pubmed: 21206992

Biochim Biophys Acta. 2011 Oct;1812(10):1314-21

pubmed: 21255645

Biochem J. 2011 May 1;435(3):755-69

pubmed: 21323643

J Med Chem. 2011 May 12;54(9):3331-47

pubmed: 21456625

Physiol Rev. 2011 Apr;91(2):651-90

pubmed: 21527734

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84

pubmed: 21670265

Handb Exp Pharmacol. 2011;(204):391-414

pubmed: 21695650

Chang Gung Med J. 2012 May-Jun;35(3):197-210

pubmed: 22735051

Pharmacol Rev. 2013 Feb 27;65(2):670-709

pubmed: 23447132

J Biomol Screen. 2013 Oct;18(9):1132-7

pubmed: 23653393

Am J Respir Cell Mol Biol. 2014 Mar;50(3):549-58

pubmed: 24106801

J Am Soc Nephrol. 2014 Feb;25(2):232-7

pubmed: 24158982

FASEB J. 2014 Feb;28(2):791-801

pubmed: 24200884

J Am Soc Nephrol. 2014 Jan;25(1):18-32

pubmed: 24335972

Br J Pharmacol. 2014 May;171(9):2385-98

pubmed: 24467222

Br J Cancer. 2014 Mar 4;110(5):1278-87

pubmed: 24518597

Biochem J. 2014 May 1;459(3):539-50

pubmed: 24555506

Pflugers Arch. 1988 Apr;411(4):450-5

pubmed: 2456518

Nat Rev Drug Discov. 2014 Apr;13(4):290-314

pubmed: 24687066

Proc Natl Acad Sci U S A. 1989 Aug;86(15):6007-11

pubmed: 2474825

Cell Signal. 2015 Apr;27(4):756-69

pubmed: 25546709

Cell Signal. 2015 May;27(5):908-22

pubmed: 25683917

Trends Pharmacol Sci. 2015 Apr;36(4):203-14

pubmed: 25744542

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1414-22

pubmed: 25775568

Nat Rev Nephrol. 2015 Aug;11(8):451-64

pubmed: 25870007

Curr Drug Targets. 2017;18(8):950-957

pubmed: 25915482

Lancet. 2015 May 16;385(9981):1993-2002

pubmed: 26090645

Kidney Int. 2015 Oct;88(4):699-710

pubmed: 26200945

J Am Soc Nephrol. 2016 Apr;27(4):1124-34

pubmed: 26289612

Cell Signal. 2016 Jul;28(7):719-24

pubmed: 26562185

Prog Biophys Mol Biol. 2016 Jan;120(1-3):28-36

pubmed: 26772438

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F577-F588

pubmed: 28077374

Kidney Int. 2018 Feb;93(2):403-415

pubmed: 29042084

Biochem J. 1980 May 1;187(2):381-92

pubmed: 6249268

Mol Pharmacol. 1995 Oct;48(4):616-22

pubmed: 7476886

J Pharmacol Exp Ther. 1995 Jun;273(3):1396-402

pubmed: 7791113

J Biol Chem. 1996 Jul 12;271(28):16526-34

pubmed: 8663227

Mol Pharmacol. 1997 Feb;51(2):242-9

pubmed: 9203629

Cell Signal. 1997 May-Jun;9(3-4):227-36

pubmed: 9218122

Biochem J. 1997 Dec 1;328 ( Pt 2):539-48

pubmed: 9371713

J Pharmacol Exp Ther. 1998 Jan;284(1):420-6

pubmed: 9435206

Biochem J. 1998 Jul 1;333 ( Pt 1):139-49

pubmed: 9639573