A cellular census of human lungs identifies novel cell states in health and in asthma.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
08
08
2018
accepted:
25
04
2019
pubmed:
19
6
2019
medline:
15
11
2019
entrez:
19
6
2019
Statut:
ppublish
Résumé
Human lungs enable efficient gas exchange and form an interface with the environment, which depends on mucosal immunity for protection against infectious agents. Tightly controlled interactions between structural and immune cells are required to maintain lung homeostasis. Here, we use single-cell transcriptomics to chart the cellular landscape of upper and lower airways and lung parenchyma in healthy lungs, and lower airways in asthmatic lungs. We report location-dependent airway epithelial cell states and a novel subset of tissue-resident memory T cells. In the lower airways of patients with asthma, mucous cell hyperplasia is shown to stem from a novel mucous ciliated cell state, as well as goblet cell hyperplasia. We report the presence of pathogenic effector type 2 helper T cells (T
Identifiants
pubmed: 31209336
doi: 10.1038/s41591-019-0468-5
pii: 10.1038/s41591-019-0468-5
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1153-1163Subventions
Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
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