Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms.
Childhood trauma
General population
Genetic liability
Gene–environment interaction
Psychotic symptoms
Journal
Social psychiatry and psychiatric epidemiology
ISSN: 1433-9285
Titre abrégé: Soc Psychiatry Psychiatr Epidemiol
Pays: Germany
ID NLM: 8804358
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
06
07
2018
accepted:
08
04
2019
pubmed:
19
6
2019
medline:
25
12
2019
entrez:
19
6
2019
Statut:
ppublish
Résumé
Whilst childhood trauma (CT) is a known risk factor across the spectrum of psychosis expression, little is known about possible interplay with genetic liability. The TwinssCan Study collected data in general population twins, focussing on expression of psychosis at the level of subthreshold psychotic experiences. A multilevel mixed-effects linear regression analysis was performed including 745 subjects to assess the interaction between genetic liability and CT. The Symptom Checklist-90 (SCL-90-R) score of the co-twin was used as an indirect measure of genetic liability to psychopathology, while the Childhood Trauma Questionnaire Short-Form (CTQ-SF) was used to assess CT in the domains of physical, emotional and sexual abuse, as well as physical and emotional neglect. The Community Assessment of Psychic Experience (CAPE) questionnaire was used to phenotypically characterize psychosis expression. In the model using the CAPE total score, the interaction between CT and genetic liability was close to statistical significance (χ The results suggest that the impact of CT on subthreshold expression of psychosis, particularly in the negative subdomain, may be larger in the co-presence of significant genetic liability for psychopathology.
Identifiants
pubmed: 31209522
doi: 10.1007/s00127-019-01711-z
pii: 10.1007/s00127-019-01711-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1045-1054Subventions
Organisme : EU-GEI
ID : HEALTH-F2-2009-241909
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