Cerebral Expression of Glial Fibrillary Acidic Protein, Ubiquitin Carboxy-Terminal Hydrolase-L1, and Matrix Metalloproteinase 9 After Traumatic Brain Injury and Secondary Brain Insults in Rats.
GFAP
MMP-9
UCH-L1
hypotension
hypoxia
traumatic brain injury
Journal
Biomarker insights
ISSN: 1177-2719
Titre abrégé: Biomark Insights
Pays: United States
ID NLM: 101288638
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
04
2019
accepted:
25
04
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
19
6
2019
Statut:
epublish
Résumé
Glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), and matrix metalloproteinase 9 (MMP-9) are potential biomarkers of traumatic brain injury (TBI) but also of secondary insults to the brain. The aim of this study was to describe the cerebral distribution of GFAP, UCH-L1, and MMP-9 in a rat model of diffuse TBI associated with standardized hypoxia-hypotension (HH). Adult male Sprague-Dawley rats were allocated to Sham (n = 10), TBI (n = 10), HH (n = 10), and TBI+HH (n = 10) groups. After 4 hours, brains were rapidly removed and immunostaining of GFAP, UCH-L1, and MMP-9 was performed. Areas of interest that have been described as particularly sensitive to hypoxic insults were analyzed. For GFAP, in the neocortex, immunostaining revealed a significant decrease in strong staining for HH and TBI+HH groups compared with TBI group (
Identifiants
pubmed: 31210728
doi: 10.1177/1177271919851515
pii: 10.1177_1177271919851515
pmc: PMC6552356
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1177271919851515Déclaration de conflit d'intérêts
Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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