Subchondral bone remodelling in osteoarthritis.
bone remodelling
osteoarthritis
subchondral
Journal
EFORT open reviews
ISSN: 2058-5241
Titre abrégé: EFORT Open Rev
Pays: England
ID NLM: 101695674
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
19
6
2019
Statut:
epublish
Résumé
Subchondral bone remodelling is an integral part of osteoarthritis and involves the development of subchondral sclerosis seen on plain imaging, along with osteophyte formation.The development of these changes is due to persistent abnormal mechanical stresses which create a cellular and biomolecular response to microfractures in the subchondral bone and osteochondral junction.An early sign is bone marrow lesions seen on MRI scanning. Healing can occur at this stage by correcting the abnormal loads. Persistence leads to what is thought to be a delayed union or nonunion response by the bone.Microfractures of the osteochondral junction, coupled with articular cartilage fissuring and loss, allows synovial fluid to penetrate the subchondral bone along with cytokines and other molecules reacting with the bone cells to increase the pathological effects.This review gives an overview of the current thoughts on subchondral bone remodelling in osteoarthritis that is aimed at orthopaedic surgeons to help in the understanding of the pathogenesis of osteoarthritis and the role of surgical management. Cite this article:
Identifiants
pubmed: 31210964
doi: 10.1302/2058-5241.4.180102
pii: 10.1302_2058-5241.4.180102
pmc: PMC6549114
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
221-229Déclaration de conflit d'intérêts
ICMJE Conflict of interest statement: The author reports royalties from Corin/Tornier, outside the submitted work.
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