Effect of Vitamin K2 on Postural Sway in Older People Who Fall: A Randomized Controlled Trial.
falls
health economic analysis
postural sway
recruitment
vitamin K
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
01
04
2019
revised:
12
05
2019
accepted:
19
05
2019
pubmed:
19
6
2019
medline:
19
5
2020
entrez:
19
6
2019
Statut:
ppublish
Résumé
Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. Parallel-group double-blind randomized placebo-controlled trial. Fourteen primary care practices in Scotland, UK. A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: -.19 cm [95% confidence interval [CI] -.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI -.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI -.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. J Am Geriatr Soc 67:2102-2107, 2019.
Identifiants
pubmed: 31211416
doi: 10.1111/jgs.16024
pmc: PMC6851824
doi:
Substances chimiques
Vitamins
0
Vitamin K 2
11032-49-8
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2102-2107Subventions
Organisme : Chief Scientist Office
ID : HERU1
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.
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