Amperometric sarcosine biosensor with strong anti-interference capabilities based on mesoporous organic-inorganic hybrid materials.
Amperometric biosensor
Anti-interference
Prostate cancer screening
Sarcosine
Surface potential
Journal
Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289
Informations de publication
Date de publication:
15 Sep 2019
15 Sep 2019
Historique:
received:
06
05
2019
revised:
05
06
2019
accepted:
08
06
2019
pubmed:
19
6
2019
medline:
23
1
2020
entrez:
19
6
2019
Statut:
ppublish
Résumé
Amperometric enzyme biosensors are some of the simplest and cheapest types of medical devices used in the rapid detection of biomarkers that have been developed in the past fifty years. When the concentrations of biomarkers are at micromoles per liter, such as for sarcosine, which was recently discovered as a biomarker for prostate cancer, the response signal of the interferences is huge, and the biosensor is hard to satisfy the requirements of practical applications. In this manuscript, we describe a strategy for synthesizing a surface electronegative organic-inorganic hybrid mesoporous material, which could reduce the interference signal much better than Nafion and Chitosan. We verify that the surface potential of the carrier nanomaterial plays an important role in excluding anionic interferences. We also prepare a sensitive (16.35 μA mM
Identifiants
pubmed: 31212197
pii: S0956-5663(19)30510-X
doi: 10.1016/j.bios.2019.111431
pii:
doi:
Substances chimiques
Sarcosine
Z711V88R5F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111431Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.