Spinal Intramedullary Ganglioglioma in Children: An Unusual Location of a Common Pediatric Tumor.
BRAF mutation
Ganglioglioma
Management
Pediatric tumor
Spinal tumor
Journal
Pediatric neurosurgery
ISSN: 1423-0305
Titre abrégé: Pediatr Neurosurg
Pays: Switzerland
ID NLM: 9114967
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
02
2019
accepted:
16
04
2019
pubmed:
19
6
2019
medline:
24
1
2020
entrez:
19
6
2019
Statut:
ppublish
Résumé
Ganglioglioma is a common CNS tumor in children, mostly found in the temporal lobe, causing epilepsy. Spinal gangliogliomas are very rare, accounting for 1.1% of all intramedullary spinal tumors. The management principles and the need for adjuvant therapy are not yet well defined in this cohort. BRAF V600E mutation in spinal ganglioglioma has been described in a few series recently. In this report, we describe 3 children with spinal ganglioglioma at different locations, and their expression of BRAF V600E mutation and follow-up. In addition, we review the recent literature on pediatric spinal ganglioglioma management.
Identifiants
pubmed: 31212295
pii: 000500427
doi: 10.1159/000500427
doi:
Substances chimiques
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-252Informations de copyright
© 2019 S. Karger AG, Basel.