Impact of porcine circovirus type 2 (PCV2) infection on hepatitis E virus (HEV) infection and transmission under experimental conditions.
Co-infection
HEV
Infection kinetic
PCV2
Transmission experiment
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
25
02
2019
revised:
09
05
2019
accepted:
09
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
9
8
2019
Statut:
ppublish
Résumé
Hepatitis E virus is a zoonotic pathogen for which pigs have been identified as the main reservoir in industrialised countries. HEV infection dynamics in pig herds and pigs are influenced by several factors, including herd practices and possibly co-infection with immunomodulating viruses. This study therefore investigates the impact of porcine circovirus type 2 (PCV2) on HEV infection and transmission through experimental HEV/PCV2 co-infection of specific-pathogen-free pigs. No statistical difference between HEV-only and HEV/PCV2-infected animals was found for either the infectious period or the quantity of HEV shed in faeces. The HEV latency period was shorter for HEV/PCV2 co-infected pigs than for HEV-only infected pigs (11.6 versus 12.3 days). Its direct transmission rate was three times higher in cases of HEV/PCV2 co-infection than in cases of HEV-only infection (0.12 versus 0.04). On the other hand, the HEV transmission rate through environmental accumulation was lower in cases of HEV/PCV2 co-infection (4.3·10
Identifiants
pubmed: 31213264
pii: S0378-1135(19)30243-3
doi: 10.1016/j.vetmic.2019.05.010
pii:
doi:
Types de publication
Clinical Trial, Veterinary
Journal Article
Langues
eng
Pagination
1-7Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.