Development of an aerosolized Mannheimia haemolytica experimental pneumonia model in clean-catch colostrum-deprived calves.
Aerosols
Age Factors
Animals
Bronchopneumonia
/ microbiology
Cattle
Cattle Diseases
/ microbiology
Colostrum
Disease Models, Animal
Female
Fibrinogen
/ analysis
Haptoglobins
/ analysis
Lung
/ microbiology
Mannheimia haemolytica
/ pathogenicity
Neutrophils
/ microbiology
Pneumonia, Bacterial
/ veterinary
Pulmonary Alveoli
/ microbiology
Aerosolization
Bovine respiratory disease
Cattle
Diffuse alveolar damage
Experimental disease
Mannheimia haemolytica
Pneumonia
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
24
02
2019
revised:
17
05
2019
accepted:
18
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
9
8
2019
Statut:
ppublish
Résumé
Mannheimia haemolytica is an important cause of bovine respiratory disease (BRD). BRD is usually a multifactorial disease with host factors and viral infections influencing pathogenesis. Previous studies that have attempted to experimentally induce pneumonia using aerosolized M. haemolytica alone have produced inconsistent results, yet an aerosol model would be useful to study the details of early infection and to investigate the role of innate defences in pathogenesis. The objective of these studies was to develop and characterize an aerosolized M. haemolytica disease model. In an initial study, conventionally raised calves with higher levels of antibody against M. haemolytica leukotoxin developed acute respiratory distress and diffuse alveolar damage, but did not develop bronchopneumonia, following challenge with M. haemolytica serotype 1. Clean-catch colostrum-deprived calves challenged with 1 × 10
Identifiants
pubmed: 31213270
pii: S0378-1135(19)30252-4
doi: 10.1016/j.vetmic.2019.05.012
pii:
doi:
Substances chimiques
Aerosols
0
Haptoglobins
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Pagination
34-43Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.