A combined metabolomic and bioinformatic approach to investigate the function of transport proteins of the important pathogen Mycoplasma bovis.
Metabolomics
Mycoplasma bovis
Transport proteins
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
27
11
2018
revised:
03
05
2019
accepted:
07
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
9
8
2019
Statut:
ppublish
Résumé
Mycoplasma bovis is an economically important pathogen of the cattle industry worldwide, and there is an urgent need for a more effective vaccine to control the diseases caused by this organism. Although the M. bovis genome sequence is available, very few gene functions of M. bovis have been experimentally determined, and a better understanding of the genes involved in pathogenesis are required for vaccine development. In this study, we compared the metabolite profiles of wild type M. bovis to a number of strains that each contained a transposon insertion into a putative transporter gene. Transport systems are thought to play an important role in survival of mycoplasmas, as they rely on the host for many nutrients. We also performed
Identifiants
pubmed: 31213276
pii: S0378-1135(18)31387-7
doi: 10.1016/j.vetmic.2019.05.008
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Carrier Proteins
0
Biopterins
0
Types de publication
Journal Article
Langues
eng
Pagination
8-16Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.