Temporal changes in the transcriptomic profile of granulosa cells of pigs treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Animals Cells, Cultured Environmental Pollutants / pharmacology Female Gene Expression Profiling / veterinary Granulosa Cells / drug effects Microarray Analysis Ovulation / drug effects Polychlorinated Dibenzodioxins / pharmacology Swine / genetics Time Factors Transcriptome / drug effects
Granulosa cells Multifactorial analysis Over-time changes Pig TCDD Transcriptome

Journal

Animal reproduction science
ISSN: 1873-2232
Titre abrégé: Anim Reprod Sci
Pays: Netherlands
ID NLM: 7807205

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 14 02 2019
revised: 15 05 2019
accepted: 04 06 2019
pubmed: 20 6 2019
medline: 18 1 2020
entrez: 20 6 2019
Statut: ppublish

Résumé

The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) compound is an environmental chemical adversely affecting reproductive processes. Intracellular TCDD effects are mediated via aryl hydrocarbon receptor (AhR). The aim of the current study was to identify genes linking the AhR pathway with phenotypic consequences of TCDD action in granulosa cells of pigs. By applying multifactorial analysis, with TCDD and incubation time as factors, it was possible to determine temporal changes induced by TCDD in the cell transcriptome. Among the identified 144 differentially expressed genes (DEGs; P

Identifiants

DOI: 10.1016/j.anireprosci.2019.06.007 PMID: 31213330
pubmed: 31213330
pii: S0378-4320(19)30128-9
doi: 10.1016/j.anireprosci.2019.06.007
pii:
doi:

Substances chimiques

Environmental Pollutants 0
Polychlorinated Dibenzodioxins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

83-94

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Anna Nynca (A)

Laboratory of Molecular Diagnostics, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Prawochenskiego 5, 10-720, Olsztyn, Poland. Electronic address: anna.nynca@uwm.edu.pl.

Agnieszka Sadowska (A)

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: agnieszka.sadowska@uwm.edu.pl.

Lukasz Paukszto (L)

Department of Plant Physiology, Genetics and Biotechnology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: pauk24@gmail.com.

Tomasz Molcan (T)

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: tomasz.molcan@uwm.edu.pl.

Monika Ruszkowska (M)

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: monika.ruszkowska@uwm.edu.pl.

Sylwia Swigonska (S)

Laboratory of Molecular Diagnostics, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Prawochenskiego 5, 10-720, Olsztyn, Poland. Electronic address: sylwia.swigonska@uwm.edu.pl.

Karina Orlowska (K)

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: karina.orlowska@uwm.edu.pl.

Kamil Myszczynski (K)

Department of Botany and Nature Protection, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Plac Lodzki 1, 10-727, Olsztyn, Poland. Electronic address: kamil.myszczynski@uwm.edu.pl.

Jan P Jastrzebski (JP)

Department of Plant Physiology, Genetics and Biotechnology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: bioinformatyka@gmail.com.

Renata E Ciereszko (RE)

Laboratory of Molecular Diagnostics, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Prawochenskiego 5, 10-720, Olsztyn, Poland; Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. Electronic address: reniac@uwm.edu.pl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Cellules › Cellules cultivées › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules de la granulosa › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Techniques d'investigation › Procédures d'analyse sur micropuce › Analyse sur microréseau › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Ovulation › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzodioxines polychlorées › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Temporal changes in the transcriptomic profile...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Temporal changes in the transcriptomic profile...