A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy.


Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 09 2019
Historique:
received: 25 03 2019
revised: 01 05 2019
accepted: 28 05 2019
pubmed: 20 6 2019
medline: 17 6 2020
entrez: 20 6 2019
Statut: ppublish

Résumé

Cancer scientists and clinicians are mourning the death of one of the most accomplished members of their community: Dr. John Mendelsohn. He was a pioneer in targeted cancer therapy and was instrumental for the discovery and deployment of the first antagonist epidermal growth factor receptor (EGFR) therapeutic antibodies, broadening the concept of targeted EGFR therapy to encompass other receptor tyrosine kinases, such as HER2, and developing blocking antibody-combination therapy with chemotherapies or radiotherapy. Dr. Mendelsohn, who died on January 7, 2019, always led by the strength of his accomplishments and the humility of his character. Above all, he was a well-revered mentor and clinician, who extended compassion and the gift of his time to patients, colleagues, and mentees alike. In tribute to Dr. Mendelsohn,

Identifiants

pubmed: 31213466
pii: 0008-5472.CAN-19-0989
doi: 10.1158/0008-5472.CAN-19-0989
doi:

Substances chimiques

Antibodies, Monoclonal 0
EGFR protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1
Trastuzumab P188ANX8CK

Types de publication

Biography Historical Article Journal Article Portrait Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

4315-4323

Sujets (noms de personnes)

{'last_name': 'Mendelsohn', 'fore_name': 'John', 'initials': 'J'}

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Rakesh Kumar (R)

Cancer Biology Program, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India. rakeshkumar@rgcb.res.in.
Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Department of Medicine, Division of Hematology-Oncology, Rutgers New Jersey Medical School, Newark, New Jersey.

Marc Van de Vijver (MV)

Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands.

Giampaolo Tortora (G)

Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario Gemelli, IRCCS, Rome, Italy.
Medical Oncology, Catholic University of the Sacred Heart, Rome, Italy.

Fortunato Ciardiello (F)

Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.

Tzipora Goldkorn (T)

University of California Davis School of Medicine, Davis, California.

Wilson H Miller (WH)

Department of Medicine, Segal Cancer Center and Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

Larry Norton (L)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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Classifications MeSH