Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus.
BK-channels
CaMK
ERK
GDPs
PI3K
immature networks
leptin
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
02
2019
accepted:
21
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
20
6
2019
Statut:
epublish
Résumé
The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. Sound data indicate that this hormone also acts as an important developmental signal impacting a number of brain regions during fetal and postnatal stages. Leptin levels surge during the two first postnatal weeks of life in rodents. This period is characterized by the presence of early network driven activity in the immature hippocampus, the so-called Giant Depolarizing Potentials (GDPs). GDPs are thought to contribute to the wiring of the hippocampal network. We therefore tested the effect of leptin on GDPs. Leptin increased GDPs frequency between the postnatal days (P) 1 and 3 via a calcium/Calmodulin-dependent kinase (CaMK) and extracellular signal-related kinase (ERK) dependent pathways. Between P6 and P7, leptin inhibited the frequency of GDPs through the activation of large conductance Ca
Identifiants
pubmed: 31213989
doi: 10.3389/fncel.2019.00254
pmc: PMC6558146
doi:
Types de publication
Journal Article
Langues
eng
Pagination
254Subventions
Organisme : NICHD NIH HHS
ID : R01 HD092369
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD092396
Pays : United States
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