Sjogren's Syndrome and TAM Receptors: A Possible Contribution to Disease Onset.
Animals
Apoptosis
Disease Models, Animal
Disease Susceptibility
Humans
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Transgenic
Proto-Oncogene Proteins
/ metabolism
Receptor Protein-Tyrosine Kinases
/ metabolism
Signal Transduction
Sjogren's Syndrome
/ etiology
c-Mer Tyrosine Kinase
/ metabolism
Axl Receptor Tyrosine Kinase
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
01
2019
revised:
17
04
2019
accepted:
28
04
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Sjogren's syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands. Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature. Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling. This review examines the relationship between TAM receptor dysfunction and SS and explores the potential contributions of TAM defects on macrophages to SS development.
Identifiants
pubmed: 31214622
doi: 10.1155/2019/4813795
pmc: PMC6535826
doi:
Substances chimiques
Proto-Oncogene Proteins
0
MERTK protein, human
EC 2.7.10.1
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
TYRO3 protein, human
EC 2.7.10.1
c-Mer Tyrosine Kinase
EC 2.7.10.1
Axl Receptor Tyrosine Kinase
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4813795Subventions
Organisme : NIDCR NIH HHS
ID : T90 DE021990
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028544
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE018958
Pays : United States
Organisme : NIDCR NIH HHS
ID : K99 DE018958
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE023433
Pays : United States
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