New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies.
Journal
Chemical Society reviews
ISSN: 1460-4744
Titre abrégé: Chem Soc Rev
Pays: England
ID NLM: 0335405
Informations de publication
Date de publication:
01 Jul 2019
01 Jul 2019
Historique:
pubmed:
20
6
2019
medline:
20
7
2019
entrez:
20
6
2019
Statut:
ppublish
Résumé
Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.
Substances chimiques
Boranes
0
Enzymes
0
Hypoxia-Inducible Factor 1
0
Ligands
0
Receptors, Androgen
0
Receptors, Calcitriol
0
Receptors, Estrogen
0
Receptors, Purinergic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM