In vivo gadolinium nanoparticle quantification with SPECT/CT.
AGuIX
Nanoparticles
Quantification
SPECT
in vivo
Journal
EJNMMI physics
ISSN: 2197-7364
Titre abrégé: EJNMMI Phys
Pays: Germany
ID NLM: 101658952
Informations de publication
Date de publication:
18 Jun 2019
18 Jun 2019
Historique:
received:
07
02
2019
accepted:
13
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
20
6
2019
Statut:
epublish
Résumé
Gadolinium nanoparticles (Gd-NP) combined with radiotherapy are investigated for radiation dose enhancement in radiotherapy treatment. Indeed, NPs concentrated in a tumor could enhance its radiosensitization. The noninvasive quantification of the NP concentration is a crucial task for radiotherapy treatment planning and post-treatment monitoring as it will determine the absorbed dose. In this work, we evaluate the achievable accuracy of in vivo SPECT-based Gd-NP organ concentration on rats. Gd-NPs were labeled with The accuracy for the Gd mass measurements in organ was within 10% for activity above 2 MBq or concentrations above ∼ 3-4 MBq/mL. The Gd mass calculation is based on In-Gd coefficient which defines the Gd detection limit. It was found to be in a range from 2 mg/MBq to 2 µg/MBq depending on the proportions of initial injection preparations. Measurement was also impaired by free Gd and Even if SPECT image quantification remains challenging mostly due to partial volume effect, this study shows that it has potential for the Gd mass measurements in organ. The main limitation of the method is its indirectness, and a special care should be taken if the organ of interest could be influenced by different clearance rate of free Gd and
Sections du résumé
BACKGROUND
BACKGROUND
Gadolinium nanoparticles (Gd-NP) combined with radiotherapy are investigated for radiation dose enhancement in radiotherapy treatment. Indeed, NPs concentrated in a tumor could enhance its radiosensitization. The noninvasive quantification of the NP concentration is a crucial task for radiotherapy treatment planning and post-treatment monitoring as it will determine the absorbed dose. In this work, we evaluate the achievable accuracy of in vivo SPECT-based Gd-NP organ concentration on rats.
METHODS
METHODS
Gd-NPs were labeled with
RESULTS
RESULTS
The accuracy for the Gd mass measurements in organ was within 10% for activity above 2 MBq or concentrations above ∼ 3-4 MBq/mL. The Gd mass calculation is based on In-Gd coefficient which defines the Gd detection limit. It was found to be in a range from 2 mg/MBq to 2 µg/MBq depending on the proportions of initial injection preparations. Measurement was also impaired by free Gd and
CONCLUSIONS
CONCLUSIONS
Even if SPECT image quantification remains challenging mostly due to partial volume effect, this study shows that it has potential for the Gd mass measurements in organ. The main limitation of the method is its indirectness, and a special care should be taken if the organ of interest could be influenced by different clearance rate of free Gd and
Identifiants
pubmed: 31214809
doi: 10.1186/s40658-019-0246-y
pii: 10.1186/s40658-019-0246-y
pmc: PMC6582109
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9Subventions
Organisme : ITMO Cancer
ID : PC201618
Organisme : SIRIC LYriCAN Grant INCa- INSERM
ID : DGOS-12563
Organisme : LABEX PRIMES
ID : ANR-11-LABX-0063
Organisme : Investissements d'Avenir (ANR)
ID : ANR- 11-IDEX-0007
Organisme : ANR2014
ID : CHONDRAD
Références
J Nucl Med. 2003 Aug;44(8):1243-52
pubmed: 12902414
Phys Med Biol. 2004 Sep 21;49(18):N309-15
pubmed: 15509078
J Nucl Med. 1992 Apr;33(4):605-12
pubmed: 1552349
J Cereb Blood Flow Metab. 1992 Jul;12(4):571-83
pubmed: 1618936
J Nucl Med Technol. 2008 Mar;36(1):1-10
pubmed: 18287196
Colloids Surf B Biointerfaces. 2009 Aug 1;72(1):128-34
pubmed: 19414242
Eur J Nucl Med Mol Imaging. 2011 May;38 Suppl 1:S69-77
pubmed: 21484383
ACS Nano. 2011 Dec 27;5(12):9566-74
pubmed: 22040385
Phys Med Biol. 2012 Nov 7;57(21):R119-59
pubmed: 23073343
Med Phys. 2015 Feb;42(2):1119-28
pubmed: 25652523
Cancer Nanotechnol. 2015;6(1):4
pubmed: 26345984
Cancer Nanotechnol. 2014;5(1):4
pubmed: 26561512
Magn Reson Imaging. 2016 Dec;34(10):1355-1358
pubmed: 27693606
Nanomedicine (Lond). 2017 May;12(10):1095-1099
pubmed: 28447906
J Appl Clin Med Phys. 2017 Jul;18(4):215-223
pubmed: 28508491
Nanomedicine (Lond). 2017 Jul;12(13):1561-1574
pubmed: 28621567