Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery.

Drug Discovery / methods Humans Pharmaceutical Preparations / metabolism Tissue Distribution
PBPK Volume of distribution (VDss) allometry extrapolation preclinical Øie-Tozer equation

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Mar 2020
Historique:
pubmed: 20 6 2019
medline: 14 3 2020
entrez: 20 6 2019
Statut: ppublish

Résumé

The performance of eight different methods to predict human volume of distribution (VD

Identifiants

DOI: 10.1080/00498254.2019.1625084 PMID: 31215316
pubmed: 31215316
doi: 10.1080/00498254.2019.1625084
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

270-279

Auteurs

Carl Petersson (C)

NCE DMPK, Discovery Technology, HealthCare Merck KGaA, Darmstadt, Germany.

Orestis Papasouliotis (O)

Merck Institute for Pharmacometrics (an affiliate of HealthCare Merck KGaA, Darmstadt, Germany), Lausanne, Switzerland).

Marc Lecomte (M)

NCE DMPK, Discovery Technology, HealthCare Merck KGaA, Darmstadt, Germany.

Lassina Badolo (L)

NCE DMPK, Discovery Technology, HealthCare Merck KGaA, Darmstadt, Germany.

Hugues Dolgos (H)

R&D, HealthCare Merck KGaA, Darmstadt, Germany.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Prediction of volume of distribution in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prediction of volume of distribution in...
questionsmedicales.fr › Préparations pharmaceutiques › Prediction of volume of distribution in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Prediction of volume of distribution in...