Development of a biochemical marker to detect current breast milk intake.
breastfeeding
carbohydrate biochemistry
health promotion
milk human
oligosaccharides
programme evaluation
Journal
Maternal & child nutrition
ISSN: 1740-8709
Titre abrégé: Matern Child Nutr
Pays: England
ID NLM: 101201025
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
03
04
2019
revised:
06
06
2019
accepted:
06
06
2019
pubmed:
20
6
2019
medline:
29
1
2021
entrez:
20
6
2019
Statut:
ppublish
Résumé
The WHO recommends exclusive breastfeeding for 6 months, but despite interventions, breastfeeding rates remain stubbornly low. Financial voucher incentives have shown promise but require a biomarker for validation of intake. This study aimed to develop a simple biochemical assay of infant urine that would tell if an infant was receiving any breast milk to validate maternal report. Urine samples were collected and snap frozen from 34 infants attending with minor illness or feeding problems, of whom 12 infants were exclusively breastfed, nine exclusively formula fed, and 11 mixed breast/formula fed. High-performance anion exchange chromatography was used to identify discriminating patterns of monosaccharide composition of unconjugated glycans in a sequence of three experiments. The absolute concentration of all human milk oligosaccharides measured blind could detect "any breastfeeding" only with a sensitivity of 48% and specificity of 78%. Unblinded examination of N-acetylglucosamine (GlcNAc) measured as GlcNH
Identifiants
pubmed: 31216094
doi: 10.1111/mcn.12859
pmc: PMC7038895
doi:
Substances chimiques
Biomarkers
0
Monosaccharides
0
Oligosaccharides
0
Mannose
PHA4727WTP
Acetylglucosamine
V956696549
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12859Subventions
Organisme : Medical Research Council
ID : MR/J000434/1
Pays : United Kingdom
Informations de copyright
© 2019 Authors. Maternal & Child Nutrition Published by John Wiley & Sons Ltd.
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