Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.

Female Humans Large-Conductance Calcium-Activated Potassium Channels / metabolism Male Nitric Oxide Synthase / metabolism Prostaglandin-Endoperoxide Synthases / metabolism Regional Blood Flow / drug effects Skin / blood supply Sweating / drug effects TRPV Cation Channels / metabolism Vasodilation / drug effects
Microcirculation Perspiration Temperature-dependent gating Temperature-sensitive ion channels Thermoregulation Warm temperature

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
05 Sep 2019
Historique:
received: 16 12 2018
revised: 14 06 2019
accepted: 14 06 2019
pubmed: 20 6 2019
medline: 31 12 2019
entrez: 20 6 2019
Statut: ppublish

Résumé

Transient receptor potential vanilloid 4 (TRPV4) channels exist in the endothelial cells of cutaneous blood vessels and the secretory cells of eccrine sweat glands. We assessed if exogenous TRPV4 channel activation elicits cutaneous vasodilatation and sweating in humans in vivo, and if so, whether this response is mediated by nitric oxide synthase (NOS)- cyclooxygenase (COX)- and/or Ca

Identifiants

DOI: 10.1016/j.ejphar.2019.172462 PMID: 31216445
pubmed: 31216445
pii: S0014-2999(19)30414-5
doi: 10.1016/j.ejphar.2019.172462
pii:
doi:

Substances chimiques

Large-Conductance Calcium-Activated Potassium Channels 0
TRPV Cation Channels 0
Nitric Oxide Synthase EC 1.14.13.39
Prostaglandin-Endoperoxide Synthases EC 1.14.99.1

Types de publication

Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

172462

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Naoto Fujii (N)

Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan. Electronic address: fujii.naoto.gb@u.tsukuba.ac.jp.

Glen P Kenny (GP)

Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Canada.

Tatsuro Amano (T)

Laboratory for Exercise and Environmental Physiology, Faculty of Education, Niigata University, Niigata, Japan.

Yasushi Honda (Y)

Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.

Narihiko Kondo (N)

Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.

Takeshi Nishiyasu (T)

Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de grande conductance › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Prostaglandin-endoperoxide synthases › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Débit sanguin régional › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Système tégumentaire › Peau › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Régulation de la température corporelle › Sudation › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Evidence for TRPV4 channel induced skin...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Evidence for TRPV4 channel induced skin...