Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation.
Amino Acid Sequence
Animals
Antibodies, Monoclonal
/ chemistry
Binding Sites
Drug Design
Humans
Matrix Metalloproteinase Inhibitors
/ chemistry
Matrix Metalloproteinases
/ chemistry
Molecular Conformation
Molecular Docking Simulation
Molecular Dynamics Simulation
Protein Binding
Structure-Activity Relationship
drug design
inhibitory antibody
matrix metalloproteinase
selectivity
tissue inhibitors of metalloproteinases
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Jun 2019
18 Jun 2019
Historique:
received:
07
05
2019
revised:
13
06
2019
accepted:
14
06
2019
entrez:
21
6
2019
pubmed:
21
6
2019
medline:
30
11
2019
Statut:
epublish
Résumé
The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis. Modulation of the target class with small molecule drugs has not led to the anticipated success until present, as all clinical trials failed due to unacceptable side effects or a lack of therapeutic outcome. Monoclonal antibodies offer a tremendous therapeutic potential given their high target selectivity and good pharmacokinetic profiles. For the treatment of a variety of diseases there are already antibody therapies available and the number is increasing. Recently, several antibodies were developed for the selective inhibition of single MMPs that showed high potency and were therefore investigated in in vivo studies with promising results. In this review, we highlight the progress that has been achieved toward the design of inhibitory antibodies that successfully modulate MMP-9 and MMP-14.
Identifiants
pubmed: 31216704
pii: molecules24122265
doi: 10.3390/molecules24122265
pmc: PMC6631688
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Matrix Metalloproteinase Inhibitors
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ZHAW
ID : 9710.3.18.5.0179
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