Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study).
Alzheimer’s disease
aging
cognition
elderly
hippocampal atrophy
weight loss
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
18 Jun 2019
18 Jun 2019
Historique:
received:
14
05
2019
revised:
06
06
2019
accepted:
07
06
2019
entrez:
21
6
2019
pubmed:
21
6
2019
medline:
15
1
2020
Statut:
epublish
Résumé
This study aimed to analyze associations between weight variation patterns and changes in cognitive function and hippocampal volume among non-demented, community-dwelling elderly. Sample was formed of 1394 adults >70 years (63.9% female), all volunteers from the Multidomain Alzheimer Preventive Trial (MAPT). Weight loss was defined as ≥5% of body weight decrease in the first year of follow-up; weight gain as ≥5% of weight increase; and stability if <5% weight variation. Cognition was examined by a Z-score combining four tests. Measures were assessed at baseline, 6, 12, 24, 36, 48, and 60 months of follow-up. Hippocampal volume was evaluated with magnetic resonance imaging in 349 subjects in the first year and at 36 months. Mixed models were performed. From the 1394 participants, 5.5% (
Identifiants
pubmed: 31216732
pii: nu11061371
doi: 10.3390/nu11061371
pmc: PMC6627683
pii:
doi:
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : French Ministry of Health
ID : PHRC 2008, 2009
Organisme : Centre Hospitalier Universitaire de Toulouse
ID : unknown grant number
Organisme : Pierre Fabre Research Institute
ID : manufacturer of the omega-3 supplement
Organisme : Exhonit Therapeutics
ID : biological sample collection
Organisme : Avid Radiopharmaceuticals
ID : PET-amyloid measurement
Organisme : Association Monegasque pour la Recherche sur la maladie d'Alzheimer
ID : unknown grant number
Organisme : UMR 1027 Unit INSERM-University of Toulouse III
ID : unknown grant number
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