Rapid weight loss with dietary salt restriction in hospitalized patients with chronic kidney disease.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 06 2019
Historique:
received: 18 01 2019
accepted: 04 06 2019
entrez: 21 6 2019
pubmed: 21 6 2019
medline: 29 10 2020
Statut: epublish

Résumé

Dietary salt restriction is essential for managing fluid retention in patients with chronic kidney disease (CKD). In this retrospective cohort study, we investigated weight loss from the perspective of fluid status in CKD patients during a 7-day hospitalization period while consuming a low-salt diet (5 g/day). Among 311 patients, the median weight loss (interquartile range, maximum) was 0.7 (0.0-1.4, 4.7) kg on Day 4 and 1.0 (0.3-1.7, 5.9) kg on Day 7. Patients were classified into quartiles based on pre-hospital urinary salt excretion (quartile [Q] 1, 1.2-5.7; Q2, 5.8-8.4; Q3, 8.5-11.3; Q4, 11.4-29.2 g/day). Weight loss was significantly greater in Q3 and Q4 than in Q1. The body mass index (BMI) and urinary salt excretion in the first 24 hours after admission were independently associated with rapid weight loss on Day 4 by multivariate logistic regression analysis. In conclusion, CKD patients with a high salt intake or high BMI exhibit rapid weight loss within a few days of consuming a low-salt diet. Dietary salt restriction is effective for reducing proteinuria in these patients, but long-term observation is needed to confirm the sustained effects.

Identifiants

pubmed: 31217504
doi: 10.1038/s41598-019-45341-6
pii: 10.1038/s41598-019-45341-6
pmc: PMC6584671
doi:

Substances chimiques

Sodium Chloride 451W47IQ8X
Sodium 9NEZ333N27

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8787

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Auteurs

Yu Mihara (Y)

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Nephrology, Omihachiman Community Medical Center, Shiga, Japan.

Hiroshi Kado (H)

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Nephrology, Omihachiman Community Medical Center, Shiga, Japan.

Isao Yokota (I)

Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.

Yayoi Shiotsu (Y)

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Kazuhiro Sonomura (K)

Department of Nephrology, Omihachiman Community Medical Center, Shiga, Japan.

Tetsuro Kusaba (T)

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Tsuguru Hatta (T)

Department of Nephrology, Omihachiman Community Medical Center, Shiga, Japan.

Satoaki Matoba (S)

Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Keiichi Tamagaki (K)

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. tamagaki@koto.kpu-m.ac.jp.

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