Progress in the emerging role of selenoproteins in cardiovascular disease: focus on endoplasmic reticulum-resident selenoproteins.
Animals
Antioxidants
/ metabolism
Cardiotonic Agents
/ therapeutic use
Cardiovascular Diseases
/ genetics
Endoplasmic Reticulum Stress
/ drug effects
Gene Expression Regulation
Glutathione Peroxidase
/ metabolism
Humans
Molecular Targeted Therapy
/ methods
Myocytes, Cardiac
/ drug effects
Oxidative Stress
/ drug effects
Peptides
/ therapeutic use
Protein Isoforms
/ agonists
Reactive Oxygen Species
/ antagonists & inhibitors
Selenocysteine
/ metabolism
Selenoproteins
/ agonists
Thioredoxin-Disulfide Reductase
/ metabolism
Biomarkers
Cardiovascular diseases
Endoplasmic reticulum
Selenoprotein T
Selenoproteins
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
27
03
2019
accepted:
14
06
2019
revised:
29
05
2019
pubmed:
21
6
2019
medline:
17
10
2019
entrez:
21
6
2019
Statut:
ppublish
Résumé
Cardiovascular diseases represent one of the most important health problems of developed countries. One of the main actors involved in the onset and development of cardiovascular diseases is the increased production of reactive oxygen species that, through lipid peroxidation, protein oxidation and DNA damage, induce oxidative stress and cell death. Basic and clinical research are ongoing to better understand the endogenous antioxidant mechanisms that counteract oxidative stress, which may allow to identify a possible therapeutic targeting/application in the field of stress-dependent cardiovascular pathologies. In this context, increasing attention is paid to the glutathione/glutathione-peroxidase and to the thioredoxin/thioredoxin-reductase systems, among the most potent endogenous antioxidative systems. These key enzymes, belonging to the selenoprotein family, have a well-established function in the regulation of the oxidative cell balance. The aim of the present review was to highlight the role of selenoproteins in cardiovascular diseases, introducing the emerging cardioprotective role of endoplasmic reticulum-resident members and in particular one of them, namely selenoprotein T or SELENOT. Accumulating evidence indicates that the dysfunction of different selenoproteins is involved in the susceptibility to oxidative stress and its associated cardiovascular alterations, such as congestive heart failure, coronary diseases, impaired cardiac structure and function. Some of them are under investigation as useful pathological biomarkers. In addition, SELENOT exhibited intriguing cardioprotective effects by reducing the cardiac ischemic damage, in terms of infarct size and performance. In conclusion, selenoproteins could represent valuable targets to treat and diagnose cardiovascular diseases secondary to oxidative stress, opening a new avenue in the field of related therapeutic strategies.
Identifiants
pubmed: 31218451
doi: 10.1007/s00018-019-03195-1
pii: 10.1007/s00018-019-03195-1
doi:
Substances chimiques
Antioxidants
0
Cardiotonic Agents
0
Peptides
0
Protein Isoforms
0
Reactive Oxygen Species
0
SELENOT protein, human
0
Selenoproteins
0
Selenocysteine
0CH9049VIS
Glutathione Peroxidase
EC 1.11.1.9
Thioredoxin-Disulfide Reductase
EC 1.8.1.9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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