An Evaluation of CD61 Immunohistochemistry in Identification of Vascular Invasion in Follicular Thyroid Neoplasms.
Adenocarcinoma, Follicular
/ pathology
Adenoma
/ pathology
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Blood Platelets
/ metabolism
Female
Humans
Immunohistochemistry
Integrin beta3
/ analysis
Male
Middle Aged
Neoplasm Invasiveness
/ pathology
Neoplastic Cells, Circulating
/ pathology
Thyroid Neoplasms
/ pathology
Young Adult
Angioinvasion
Atypical follicular adenoma
CD61
Fibrin
Follicular thyroid carcinoma
Platelets
Thrombi
Vascular invasion
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
11
04
2019
accepted:
15
06
2019
pubmed:
21
6
2019
medline:
5
2
2021
entrez:
21
6
2019
Statut:
ppublish
Résumé
The identification of vascular invasion in follicular thyroid neoplasms is essential for categorizing lesions as benign (follicular adenomas) or malignant (follicular thyroid carcinomas). Among the histologic criteria diagnostic of true vascular invasion is tumor-cell associated thrombosis, including fibrin deposition and platelet clumping. This study aims to evaluate whether an immunohistochemical stain for the platelet-associated protein CD61 could assist in identifying tumor-associated thromboses and thereby confirm vascular invasion in follicular thyroid neoplasms. Histologic review and CD61 immunostaining of 19 atypical follicular adenomas, 13 non-metastatic follicular thyroid carcinomas, and 11 metastatic follicular thyroid carcinomas was performed. Linear arrays or clustered groups of CD61-expressing intravascular platelets were present in 51% of cases overall, including 54% of follicular thyroid carcinomas and 47% of follicular adenomas, mostly within intracapsular or peritumoral vessels. In three follicular thyroid carcinomas (all with distant metastases), CD61-expressing platelets were present in association with intravascular tumor cells. This finding was not present in adenomas. CD61 staining alone did not distinguish between atypical follicular adenomas, non-metastatic carcinomas, and metastatic carcinomas. When present in association with intravascular tumor cells, however, CD61-expressing platelets may serve as a marker for vascular invasion and aid in the diagnosis of follicular thyroid carcinoma.
Identifiants
pubmed: 31218593
doi: 10.1007/s12105-019-01048-8
pii: 10.1007/s12105-019-01048-8
pmc: PMC7235115
doi:
Substances chimiques
Biomarkers, Tumor
0
ITGB3 protein, human
0
Integrin beta3
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
399-405Références
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