Impact of early adverse life events and sex on functional brain networks in patients with urological chronic pelvic pain syndrome (UCPPS): A MAPP Research Network study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
08
2018
accepted:
16
05
2019
entrez:
21
6
2019
pubmed:
21
6
2019
medline:
15
2
2020
Statut:
epublish
Résumé
Pain is a highly complex and individualized experience with biopsychosocial components. Neuroimaging research has shown evidence of the involvement of the central nervous system in the development and maintenance of chronic pain conditions, including urological chronic pelvic pain syndrome (UCPPS). Furthermore, a history of early adverse life events (EALs) has been shown to adversely impact symptoms throughout childhood and into adulthood. However, to date, the role of EAL's in the central processes of chronic pain have not been adequately investigated. We studied 85 patients (56 females) with UCPPS along with 86 healthy controls (HCs) who had resting-state magnetic resonance imaging scans (59 females), and data on EALs as a part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Study. We used graph theory methods in order to investigate the impact of EALs on measures of centrality, which characterize information flow, communication, influence, and integration in a priori selected regions of interest. Patients with UCPPS exhibited lower centrality in the right anterior insula compared to HCs, a key node in the salience network. Males with UCPPS exhibited lower centrality in the right anterior insula compared the HC males. Females with UCPPS exhibited greater centrality in the right caudate nucleus and left angular gyrus compared to HC females. Males with UCPPS exhibited lower centrality in the left posterior cingulate, angular gyrus, middle temporal gyrus, and superior temporal sulcus, but greater centrality in the precuneus and anterior mid-cingulate cortex (aMCC) compared to females with UCPPS. Higher reports of EALs was associated with greater centrality in the left precuneus and left aMCC in females with UCPPS. This study provides evidence for disease and sex-related alterations in the default mode, salience, and basal ganglia networks in patients with UCPPS, which are moderated by EALs, and associated with clinical symptoms and quality of life (QoL).
Identifiants
pubmed: 31220089
doi: 10.1371/journal.pone.0217610
pii: PONE-D-18-23190
pmc: PMC6586272
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0217610Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK082345
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082315
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082316
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082344
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082333
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK082316
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK048351
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK082333
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082325
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK106528
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082370
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082342
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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