Stress and immune response to bacterial LPS in the sea urchin Paracentrotus lividus (Lamarck, 1816).
Antimicrobical peptides
Coelomocyte
Echinoderm
HSP70
HSP90
Paracentrotus lividus
Thymosin
Journal
Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
20
12
2018
revised:
07
06
2019
accepted:
10
06
2019
pubmed:
21
6
2019
medline:
4
12
2019
entrez:
21
6
2019
Statut:
ppublish
Résumé
The immune system of the sea urchin species Paracentrotus lividus is highly complex and, as yet, poorly understood. P. lividus coelomocytes mediate immune response through phagocytosis and encapsulation of non-self particles, in addition to the production of antimicrobial molecules. Despite this understanding, details of exactly how these processes occur and the mechanisms which drive them are still in need of clarification. In this study, we show how the bacterial lipopolysaccharides (LPS) is able to induce a stress response which increases the levels of the heat shock proteins HSP70 and HSP90 only a few hours after treatment. This study also shows that LPS treatment increases the expression of the β-thymosin-derivated protein paracentrin, the precursor of antimicrobial peptides.
Identifiants
pubmed: 31220574
pii: S1050-4648(19)30664-3
doi: 10.1016/j.fsi.2019.06.017
pii:
doi:
Substances chimiques
Heat-Shock Proteins
0
Lipopolysaccharides
0
Thymosin
61512-21-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
384-394Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.