Anticancer properties of N-alkyl-2, 4-diphenylimidazo [1, 2-a] quinoxalin-1-amine derivatives; kinase inhibitors.
Antineoplastic Agents
/ chemistry
Apoptosis
Cell Proliferation
Drug Design
Drug Screening Assays, Antitumor
Humans
Molecular Docking Simulation
Molecular Structure
Neoplasms
/ drug therapy
Protein Conformation
Protein Kinase Inhibitors
/ chemistry
Proto-Oncogene Proteins c-abl
/ antagonists & inhibitors
Quinoxalines
/ chemistry
Structure-Activity Relationship
Tumor Cells, Cultured
Anticancer
Docking
Kinase inhibitor
Quinoxalin
Synthesis
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
11
2018
revised:
27
03
2019
accepted:
06
06
2019
pubmed:
21
6
2019
medline:
21
10
2020
entrez:
21
6
2019
Statut:
ppublish
Résumé
Structure activity correlation revealed that the quinoxaline ring is a satisfactory backbone for anticancer activity and a specific functional group at position 1 and 2 can improve the activity. In this basis, besides quinoxaline, imidazoles as potential anticancer agents were used as a supplementary agents for cancer treatment. In this paper, a new series of N-alkyl-2, 4-diphenylimidazo [1, 2-a] quinoxalin-1-amine derivatives were synthesized in a simple and efficient step. The products are fully characterized by 1H NMR,
Identifiants
pubmed: 31220669
pii: S0045-2068(18)31297-5
doi: 10.1016/j.bioorg.2019.103055
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Protein Kinase Inhibitors
0
Quinoxalines
0
ABL1 protein, human
EC 2.7.10.2
Proto-Oncogene Proteins c-abl
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103055Informations de copyright
Copyright © 2019. Published by Elsevier Inc.